A Dose Response Association Between Body Mass Index and Mortality in Patients with Peripheral Artery Disease: A Meta-analysis Including 5 729 272 Individuals

Obesity is a significant risk factor for atherosclerotic cardiovascular disease; however, the “obesity paradox”, in which obese patients enjoy superior survival, has been observed various conditions. Whether this phenomenon exists peripheral artery disease (PAD) remains uncertain. The goal of study was to evaluate relationship between body mass index (BMI) and mortality with PAD. A comprehensive literature search identified seven eligible cohort studies that reported association BMI all cause dose response meta-analysis done mortality, short term (30 day or hospital) long mortality. also assessed who received endovascular therapy (EVT). non-linear analysis showed higher values were associated lower from range 15 kg/m2 approximately 33 – 34 kg/m2. increased slightly thereafter. This consistent but not apparent U shaped EVT lowest at around 30 obesity paradox evident survival among PAD, rates patients. However, hospital